A biologist and mathematician (ENS 2010), Mircea T. Sofonea trained in epidemiology and infectious disease modelling (Institut Pasteur 2013) before completing his PhD on multiple infections and the evolution of virulence (Univ. Montpellier 2017), with particular interest in the evolutionary implications of non-pharmaceutical interventions during the 2013–2016 West African Ebola virus epidemic. After a postdoctoral fellowship in spatial epidemiology (CNRS 2018), he was appointed Associate Professor at the University of Montpellier, where he teaches biostatistics, epidemiology, modelling, and biomedical misinformation in biology and health curricula. He is also regularly invited to teach in France (ENS ; CNAM) and abroad (École polytechnique de Thiès, Senegal ; Faculty of Medicine of the Austral University of Chile), on topics such as viral evolution, artificial intelligence in epidemiology, and aerosol biophysics.

Throughout the COVID-19 pandemic, he contributed in particular to hospital capacity projections, estimates of the effectiveness of control measures, and assessments of the transmission advantage of SARS-CoV-2 variants. He also helped launch the ANRS MIE Coordinated Action on Modelling, now the French Research Action on Modelling Epidemics.

As the Research head of the ExposUM Institute for environmental health (since 2022), affiliated researcher at the Nîmes University Hospital (since 2023), HDR from  Faculty of Medicine of Sorbonne University (2024), his current work focuses on the quantitative integration of the scientific and public health disciplines involved in the study of, preparedness for, and response to future pandemics, using mathematical and statistical modelling as a common platform within a formal and operational framework, hygiocrisisology.