ANRS Maladies infectieuses émergentes

I am an immunovirologist whose research lies at the interface of nucleic acid immunity and virus biology. My work focuses on how mammalian cells sense and regulate RNA species generated during infection, and how these mechanisms can be leveraged to improve RNA-based therapeutics.

During my PhD, I investigated how viral RNAs are recognized by RIG-I-like receptors (RLRs) in infected cells, identifying both the RNA ligands and host protein partners involved in this process. This work contributed to a better understanding of how RIG-I, MDA5, and LGP2 discriminate between distinct viral RNA signatures to initiate antiviral responses.

I am currently based at Queen Mary University of London, where my research explores the interplay between antiviral RNA sensing pathways and self-amplifying mRNA (saRNA) technologies. In particular, I study how replication complexes, double-stranded RNA intermediates, and immune modulators influence saRNA activity in mammalian cells. More broadly, my research aims to bridge fundamental insights into nucleic acid immunity with the development of improved RNA-based technologies.

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